For solving the problem of dispersion in fiber communication, this article designed a ultra large negative dispersion regular octagonal PCF with liquid infiltration. The effects of air-hole diameter (d), layer-to-layer spacing (Λ) and refractive index of the infiltrating liquid (nL) on dispersion have been obtained based on Finite Element Method (FEM) by using COMSOL Multiphysics. The results show that with an increase of nL, the dispersion gets blue-shifted and the negative dispersion will increase. However, with the increase of Λ, the dispersion is red-shifted and the negative dispersion will reduce. Again, with the increase of d, the dispersion is red-shifted but with an augment of negative dispersion. This paper’s theoretical study shows a high negative dispersion of -13000ps/(nm·km) around 1550nm when d=1.000μm, Λ=1.500μm and nL=1.374. The Dispersion Compensating Fiber (DCF) can effectively compensate the single mode fiber G. 652, which has been widely used. One meter the DCF can compensate 650 meters G. 652.