29 February 2016 Simultaneous fingerprint and high-wavenumber fiber-optic Raman endoscopy for in vivo diagnosis of laryngeal cancer
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Abstract
We report a unique simultaneous fingerprint (FP) and high-wavenumber (HW) fiber-optic confocal Raman spectroscopy for in vivo diagnosis of laryngeal cancer in the head and neck under wide-field endoscopic imaging. The simultaneous FP and HW Raman endoscopy technique was performed on 21 patients and differentiated laryngeal carcinoma from normal tissues with both sensitivity and specificity of ~85%. This study shows the great potential of the FP/HW Raman endoscopic technique developed for in vivo diagnosis of laryngeal carcinoma during routine endoscopic examination.
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Kan Lin, Wei Zheng, Jianfeng Wang, Chwee Ming Lim, Zhiwei Huang, "Simultaneous fingerprint and high-wavenumber fiber-optic Raman endoscopy for in vivo diagnosis of laryngeal cancer", Proc. SPIE 9689, Photonic Therapeutics and Diagnostics XII, 96892B (29 February 2016); doi: 10.1117/12.2213964; https://doi.org/10.1117/12.2213964
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