29 February 2016 Characterization of atherosclerotic plaques by cross-polarization optical coherence tomography
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Abstract
We combined cross-polarization optical coherence tomography (CP OCT) and non-linear microscopy based on second harmonic generation (SHG) and two-photon-excited fluorescence (2PEF) to assess collagen and elastin fibers in the development of the atherosclerotic plaque (AP). The study shows potential of CP OCT for the assessment of collagen and elastin fibers condition in atherosclerotic arteries. Specifically, the additional information afforded by CP OCT, related to birefringence and cross-scattering properties of arterial tissues, may improve the robustness and accuracy of assessment about the microstructure and composition of the plaque for different stages of atherosclerosis.
Conference Presentation
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Ekaterina V. Gubarkova, Varvara V. Dudenkova, Felix I. Feldchtein, Lidia B. Timofeeva, Elena B. Kiseleva, Sergei S. Kuznetsov, Alexander A. Moiseev, Gregory V. Gelikonov, Alex I. Vitkin, Natalia D. Gladkova, "Characterization of atherosclerotic plaques by cross-polarization optical coherence tomography", Proc. SPIE 9689, Photonic Therapeutics and Diagnostics XII, 96893F (29 February 2016); doi: 10.1117/12.2210822; https://doi.org/10.1117/12.2210822
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