Photodynamic therapy of Cervical Intraepithelial Neoplasia (CIN) high grade

Fernanda M. Carbinatto; Natalia Mayumi Inada; Welington Lombardi; Eduardo Venerando da Silva; Renata Belotto; Cristina Kurachi; Vanderlei Salvador Bagnato

doi:10.1117/12.2213339

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29 February 2016 Photodynamic therapy of Cervical Intraepithelial Neoplasia (CIN) high grade

Fernanda M. Carbinatto, Natalia Mayumi Inada, Welington Lombardi, Eduardo Venerando da Silva, Renata Belotto, Cristina Kurachi, Vanderlei Salvador Bagnato

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Proceedings Volume 9689, Photonic Therapeutics and Diagnostics XII; 968948 (2016) https://doi.org/10.1117/12.2213339
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Cervical intraepithelial neoplasia (CIN) is the precursor of invasive cervical cancer and associated with human papillomavirus (HPV) infection. Photodynamic therapy (PDT) is a technique that has been used for the treatment of tumors. PDT is based on the accumulation of a photosensitizer in target cells that will generate cytotoxic reactive oxygen species upon illumination, inducing the death of abnormal tissue and PDT with less damaging to normal tissues than surgery, radiation, or chemotherapy and seems to be a promising alternative procedure for CIN treatment. The CIN high grades (II and III) presents potential indications for PDT due the success of PDT for CIN low grade treatment. The patients with CIN high grade that were treated with new clinic protocol shows lesion regression to CIN low grade 60 days after the treatment. The new clinical protocol using for treatment of CIN high grade shows great potential to become a public health technique.

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Fernanda M. Carbinatto, Natalia Mayumi Inada, Welington Lombardi, Eduardo Venerando da Silva, Renata Belotto, Cristina Kurachi, and Vanderlei Salvador Bagnato "Photodynamic therapy of Cervical Intraepithelial Neoplasia (CIN) high grade", Proc. SPIE 9689, Photonic Therapeutics and Diagnostics XII, 968948 (29 February 2016); https://doi.org/10.1117/12.2213339

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