Reliability analysis of instrument design of noninvasive bone marrow disease detector

Yu Su; Ting Li; Yunlong Sun

doi:10.1117/12.2210781

29 February 2016 Reliability analysis of instrument design of noninvasive bone marrow disease detector

Yu Su, Ting Li, Yunlong Sun

Proceedings Volume 9689, Photonic Therapeutics and Diagnostics XII; 96894R (2016) https://doi.org/10.1117/12.2210781
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Bone marrow is an important hematopoietic organ, and bone marrow lesions (BMLs) may cause a variety of complications with high death rate and short survival time. Early detection and follow up care are particularly important. But the current diagnosis methods rely on bone marrow biopsy/puncture, with significant limitations such as invasion, complex operation, high risk, and discontinuous. It is highly in need of a non-invasive, safe, easily operated, and continuous monitoring technology. So we proposed to design a device aimed for detecting bone marrow lesions, which was based on near infrared spectrum technology. Then we fully tested its reliabilities, including the sensitivity, specificity, signal-to-noise ratio (SNR), stability, and etc. Here, we reported this sequence of reliability test experiments, the experimental results, and the following data analysis. This instrument was shown to be very sensitive, with distinguishable concentration less than 0.002 and with good linearity, stability and high SNR. Finally, these reliability-test data supported the promising clinical diagnosis and surgery guidance of our novel instrument in detection of BMLs.

Citation Download Citation

Yu Su, Ting Li, and Yunlong Sun "Reliability analysis of instrument design of noninvasive bone marrow disease detector", Proc. SPIE 9689, Photonic Therapeutics and Diagnostics XII, 96894R (29 February 2016); https://doi.org/10.1117/12.2210781

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