Assessing the viscoelasticity of green light induced CXL in the rabbit cornea by noncontact OCE and FEM

Zhaolong Han; Jiasong Li; Manmohan Singh; Srilatha Vantipalli; Salavat R. Aglyamov; Chen Wu; Chih-hao Liu; Michael D. Twa; Kirill V. Larin

doi:10.1117/12.2208627

4 March 2016 Assessing the viscoelasticity of green light induced CXL in the rabbit cornea by noncontact OCE and FEM

Zhaolong Han, Jiasong Li, Manmohan Singh, Srilatha Vantipalli, Salavat R. Aglyamov, Chen Wu, Chih-hao Liu, Michael D. Twa, Kirill V. Larin

Author Affiliations +

Proceedings Volume 9693, Ophthalmic Technologies XXVI; 96930X (2016) https://doi.org/10.1117/12.2208627
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

The biomechanical properties of the cornea have a profound influence on its health and function. Rose bengal/green light corneal collagen cross-linking (RGX) has been proposed as an alternative to UV-A Riboflavin collagen cross-linking (UV-CXL) for treatment of keratoconus. However, the effects of RGX on the biomechanical properties of the cornea are not as well understood as UV-CXL. In this work, we demonstrate the feasibility of quantifying the viscoelasticity of the rabbit cornea before and after RGX using a noncontact method of phase-stabilized swept source optical coherence elastography (PhS-SSOCE) and finite element modeling (FEM). Viscoelastic FE models of the corneas were constructed to simulate the elastic wave propagation based on the OCE measurements. In addition, the effect of the fluid-structure interface (FSI) between the corneal posterior surface and aqueous humor on the elastic wave group velocity was also investigated. The effect of the FSI was first validated by OCE measurements and FEM simulations on contact lenses, and the OCE and FEM results were in good agreement. The Young’s modulus of the rabbit cornea before RGX was assessed as E=80 kPa, and the shear viscosity was η=0.40 Pa•s at an intraocular pressure (IOP) of 15 mmHg. After RGX, the Young’s modulus increased to E=112 kPa and shear viscosity decreased to η=0.37 Pa•s. Both the corneal OCE experiments and the FE simulations also demonstrated that the FSI significantly reduced the group velocity of the elastic wave, and thus, the FSI should be considered when determining the biomechanical properties of the cornea.

Conference Presentation

Citation Download Citation

Zhaolong Han, Jiasong Li, Manmohan Singh, Srilatha Vantipalli, Salavat R. Aglyamov, Chen Wu, Chih-hao Liu, Michael D. Twa, and Kirill V. Larin "Assessing the viscoelasticity of green light induced CXL in the rabbit cornea by noncontact OCE and FEM", Proc. SPIE 9693, Ophthalmic Technologies XXVI, 96930X (4 March 2016); https://doi.org/10.1117/12.2208627

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available