Parafoveal retinal cone mosaic imaging in children with ultra-compact switchable SLO/OCT handheld probe
(Conference Presentation)

Francesco LaRocca; Derek Nankivil; Theodore B. DuBose; Cynthia A. Toth M.D.; Sina Farsiu; Joseph A. Izatt

doi:10.1117/12.2212869

26 April 2016 Parafoveal retinal cone mosaic imaging in children with ultra-compact switchable SLO/OCT handheld probe (Conference Presentation)

Francesco LaRocca, Derek Nankivil, Theodore B. DuBose, Cynthia A. Toth M.D., Sina Farsiu, Joseph A. Izatt

Author Affiliations +

Proceedings Volume 9693, Ophthalmic Technologies XXVI; 96931I (2016) https://doi.org/10.1117/12.2212869
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

In vivo photoreceptor imaging has enhanced the way vision scientists and ophthalmologists understand the retinal structure, function, and etiology of numerous retinal pathologies. However, the complexity and large footprint of current systems capable of resolving photoreceptors has limited imaging to patients who are able to sit in an upright position and fixate for several minutes. Unfortunately, this excludes an important fraction of patients including bedridden patients, small children, and infants. Here, we show that our dual-modality, high-resolution handheld probe with a weight of only 94 g is capable of visualizing photoreceptors in supine children. Our device utilizes a microelectromechanical systems (MEMS) scanner and a novel telescope design to achieve over an order of magnitude reduction in size compared to similar systems. The probe has a 7° field of view and a lateral resolution of 8 µm. The optical coherence tomography (OCT) system has an axial resolution of 7 µm and a sensitivity of 101 dB. High definition scanning laser ophthalmoscopy (SLO) and OCT images were acquired from children ranging from 14 months to 12 years of age with and without pathology during examination under anesthesia in the operating room. Parafoveal cone imaging was shown using the SLO arm of this device without adaptive optics using a 3° FOV for the first time in children under 4 years old. This work lays the foundation for pediatric research, which will improve understanding of retinal development, maldevelopment and early onset of diseases at the cellular level during the beginning stages of human growth.

Conference Presentation

Citation Download Citation

Francesco LaRocca, Derek Nankivil, Theodore B. DuBose, Cynthia A. Toth M.D., Sina Farsiu, and Joseph A. Izatt "Parafoveal retinal cone mosaic imaging in children with ultra-compact switchable SLO/OCT handheld probe (Conference Presentation)", Proc. SPIE 9693, Ophthalmic Technologies XXVI, 96931I (26 April 2016); https://doi.org/10.1117/12.2212869

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
PRESENTATION

WATCH
PRESENTATION SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

Optical coherence tomography

Scanning laser ophthalmoscopy

Enhanced vision

Imaging systems

In vivo imaging

Microelectromechanical systems

Pathology

Show All Keywords

Keywords/Phrases

Search In:

Publication Years