Pancreas tumor interstitial pressure catheter measurement

Michael D. Nieskoski; Jason Gunn; Kayla Marra; B. Stuart Trembly; Brian W. Pogue

doi:10.1117/12.2214181

5 April 2016 Pancreas tumor interstitial pressure catheter measurement

Michael D. Nieskoski, Jason Gunn, Kayla Marra, B. Stuart Trembly, Brian W. Pogue

Proceedings Volume 9694, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXV; 969408 (2016) https://doi.org/10.1117/12.2214181
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

This paper highlights the methodology in measuring interstitial pressure in pancreatic adenocarcinoma tumors. A Millar Mikrotip pressure catheter (SPR-671) was used in this study and a system was built to amplify and filter the output signal for data collection. The Millar pressure catheter was calibrated prior to each experiment in a water column at 37°C, range of 0 to 60 inH2O (112 mmHg), resulting in a calibration factor of 33 mV / 1 inH2O. The interstitial pressures measured in two orthotopically grown pancreatic adenocarcinoma tumor were 57 mmHg and 48 mmHg, respectively. Verteporfin uptake into the pancreatic adenocarcinoma tumor was measured using a probe-based experimental dosimeter.

Conference Presentation

Citation Download Citation

Michael D. Nieskoski, Jason Gunn, Kayla Marra, B. Stuart Trembly, and Brian W. Pogue "Pancreas tumor interstitial pressure catheter measurement", Proc. SPIE 9694, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXV, 969408 (5 April 2016); https://doi.org/10.1117/12.2214181

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