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1 March 2016Development of low-cost devices for image-guided photodynamic therapy treatment of oral cancer in global health settings
Hui Liu,1 Grant Rudd,1 Liam Daly,1 Joshua Hempstead,1 Yiran Liu,1 Amjad Pervez Khan,2 Srivalleesha Mallidi,2 Richard Thomas,1 Imran Rizvi,2 Stephen Arnason,1 Filip Cuckov,1 Tayyaba Hasan,2 Jonathan P. Celli1
1Univ. of Massachusetts Boston (United States) 2Wellman Ctr. for Photomedicine, Massachusetts General Hospital (United States)
Photodynamic therapy (PDT) is a light-based modality that shows promise for adaptation and implementation as a cancer treatment technology in resource-limited settings. In this context PDT is particularly well suited for treatment of pre-cancer and early stage malignancy of the oral cavity, that present a major global health challenge, but for which light delivery can be achieved without major infrastructure requirements. In recent reports we demonstrated that a prototype low-cost batterypowered 635nm LED light source for ALA-PpIX PDT achieves tumoricidal efficacy in vitro and vivo, comparable to a commercial turn-key laser source. Here, building on these reports, we describe the further development of a prototype PDT device to enable intraoral light delivery, designed for ALA- PDT treatment of precancerous and cancerous lesions of the oral cavity. We evaluate light delivery via fiber bundles and customized 3D printed light applicators for flexible delivery to lesions of varying size and position within the oral cavity. We also briefly address performance requirements (output power, stability, and light delivery) and present validation of the device for ALA-PDT treatment in monolayer squamous carcinoma cell cultures.
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Hui Liu, Grant Rudd, Liam Daly, Joshua Hempstead, Yiran Liu, Amjad Pervez Khan, Srivalleesha Mallidi, Richard Thomas, Imran Rizvi, Stephen Arnason, Filip Cuckov, Tayyaba Hasan, Jonathan P. Celli, "Development of low-cost devices for image-guided photodynamic therapy treatment of oral cancer in global health settings," Proc. SPIE 9694, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXV, 96940C (1 March 2016);