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4 March 2016 Image-guided surgery using fluorescence: road to clinical translation of novel probes
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Fluorescence imaging using non-targeted fluorescent agents has been extensively studied during the last decade. Although proven feasible, tumor-specific imaging can be dramatically enhanced using tumor-specific fluorescent contrast agents. Clinical translation of these agents is challenging and hurdles have to be overcome. In this overview paper we recapitulate the key regulations for first-in-human studies with fluorescent agents, provide insight in different strategies for fast clinical translation and discuss how clinical introduction of the first fluorescent targeted agents was achieved.
© (2016) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Pim J. Bongers, Leonora S. F. Boogerd, Henricus J. M. Handgraaf, Charlotte E. S. Hoogstins, Cornelis J. H. van de Velde, Jacobus Burggraaf, and Alexander L. Vahrmeijer "Image-guided surgery using fluorescence: road to clinical translation of novel probes", Proc. SPIE 9696, Molecular-Guided Surgery: Molecules, Devices, and Applications II, 96960Z (4 March 2016);

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