8 March 2016 Optical coherence elastography based on high speed imaging of single-hot laser-induced acoustic waves at 16 kHz frame rate
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Abstract
Shear wave OCE (SW-OCE) is a novel technique that relies on the detection of the localized shear wave speed to map tissue elasticity. In this study, we demonstrate high speed imaging to capture single-shot transient shear wave propagation for SW-OCE. The fast imaging speed is achieved using a Fourier domain mode-locked (FDML) high-speed swept-source OCT (SS-OCT) system. The frame rate of shear wave imaging is 16 kHz, at an A-line rate of ~1.62 MHz, enabling the detection of high-frequency shear waves up to 8 kHz in bandwidth. Several measures are taken to improve the phase-stability of the SS-OCT system, and the measured displacement sensitivity is ~10 nanometers. To facilitate non-contact elastography, shear waves are generated with the photo-thermal effect using an ultra-violet pulsed laser. High frequency shear waves launched by the pulsed laser contain shorter wavelengths and carry rich localized elasticity information. Benefiting from single-shot acquisition, each SWI scan only takes 2.5 milliseconds, and the reconstruction of the elastogram can be performed in real-time with ~20 Hz refresh rate. SW-OCE measurements are demonstrated on porcine cornea ex vivo. This study is the first demonstration of an all-optical method to perform real-time 3D SW-OCE. It is hoped that this technique will be applicable in the clinic to obtain high-resolution localized quantitative measurements of tissue biomechanical properties.
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Shaozhen Song, Shaozhen Song, Bao-Yu Hsieh, Bao-Yu Hsieh, Wei Wei, Wei Wei, Tueng Shen, Tueng Shen, Ivan Pelivanov, Ivan Pelivanov, Matthew O'Donnell, Matthew O'Donnell, Ruikang K. Wang, Ruikang K. Wang, "Optical coherence elastography based on high speed imaging of single-hot laser-induced acoustic waves at 16 kHz frame rate", Proc. SPIE 9697, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XX, 96971O (8 March 2016); doi: 10.1117/12.2214809; https://doi.org/10.1117/12.2214809
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