A scalable correlator for multichannel diffuse correlation spectroscopy

Christopher J. Stapels; Noah J. Kolodziejski; Daniel McAdams; Matthew J. Podolsky; Daniel E. Fernandez; Dana Farkas; James F. Christian

doi:10.1117/12.2213114

7 March 2016 A scalable correlator for multichannel diffuse correlation spectroscopy

Christopher J. Stapels, Noah J. Kolodziejski, Daniel McAdams, Matthew J. Podolsky, Daniel E. Fernandez, Dana Farkas, James F. Christian

Author Affiliations +

Proceedings Volume 9698, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIV; 969816 (2016) https://doi.org/10.1117/12.2213114
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Diffuse correlation spectroscopy (DCS) is a technique which enables powerful and robust non-invasive optical studies of tissue micro-circulation and vascular blood flow. The technique amounts to autocorrelation analysis of coherent photons after their migration through moving scatterers and subsequent collection by single-mode optical fibers. A primary cost driver of DCS instruments are the commercial hardware-based correlators, limiting the proliferation of multi-channel instruments for validation of perfusion analysis as a clinical diagnostic metric. We present the development of a low-cost scalable correlator enabled by microchip-based time-tagging, and a software-based multi-tau data analysis method. We will discuss the capabilities of the instrument as well as the implementation and validation of 2- and 8-channel systems built for live animal and pre-clinical settings.

Citation Download Citation

Christopher J. Stapels, Noah J. Kolodziejski, Daniel McAdams, Matthew J. Podolsky, Daniel E. Fernandez, Dana Farkas, and James F. Christian "A scalable correlator for multichannel diffuse correlation spectroscopy", Proc. SPIE 9698, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIV, 969816 (7 March 2016); https://doi.org/10.1117/12.2213114

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