11 March 2016 Digital detection of biomarkers for high-sensitivity diagnostics at low-cost
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Abstract
We have demonstrated Interferometric Reflectance Imaging Sensor (IRIS) with the ability to detect single nanoscale particles. By extending single-particle IRIS to in-liquid dynamic imaging, we demonstrated real-time digital detection of individual viral pathogens as well as single molecules labeled with Au nanoparticles. With this technique we demonstrate real-time simultaneous detection of multiple targets in a single sample, as well as quantitative dynamic detection of individual biomolecular interactions for reaction kinetics measurements. This approach promises to simplify and reduce the cost of rapid diagnostics.
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M. Selim Ünlü, John Connor, Steve Scherr, George G. Daaboul, Elif Ç. Seymour, Nese Lortlar Ünlü, Jacob Trueb, Derin D. Sevenler, Oguzhan Avci, "Digital detection of biomarkers for high-sensitivity diagnostics at low-cost", Proc. SPIE 9699, Optics and Biophotonics in Low-Resource Settings II, 969902 (11 March 2016); doi: 10.1117/12.2218530; https://doi.org/10.1117/12.2218530
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