11 March 2016 Digital detection of biomarkers for high-sensitivity diagnostics at low-cost
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We have demonstrated Interferometric Reflectance Imaging Sensor (IRIS) with the ability to detect single nanoscale particles. By extending single-particle IRIS to in-liquid dynamic imaging, we demonstrated real-time digital detection of individual viral pathogens as well as single molecules labeled with Au nanoparticles. With this technique we demonstrate real-time simultaneous detection of multiple targets in a single sample, as well as quantitative dynamic detection of individual biomolecular interactions for reaction kinetics measurements. This approach promises to simplify and reduce the cost of rapid diagnostics.
© (2016) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
M. Selim Ünlü, M. Selim Ünlü, John Connor, John Connor, Steve Scherr, Steve Scherr, George G. Daaboul, George G. Daaboul, Elif Ç. Seymour, Elif Ç. Seymour, Nese Lortlar Ünlü, Nese Lortlar Ünlü, Jacob Trueb, Jacob Trueb, Derin D. Sevenler, Derin D. Sevenler, Oguzhan Avci, Oguzhan Avci, } "Digital detection of biomarkers for high-sensitivity diagnostics at low-cost", Proc. SPIE 9699, Optics and Biophotonics in Low-Resource Settings II, 969902 (11 March 2016); doi: 10.1117/12.2218530; https://doi.org/10.1117/12.2218530

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