7 March 2016 Low cost flatbed scanner label-free biosensor
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Abstract
In this paper, we demonstrate utilization of a commercial flatbed document scanner as a label-free biosensor for highthroughput imaging of DNA and protein microarrays. We implemented an interferometric sensing technique through use of a silicon/oxide layered substrate, and easy to implement hardware modifications such as re-aligning moving parts and inserting a custom made sample plate. With a cost as low as 100USD, powered by a USB cable, and scan speed of 30 seconds for a 4mm x 4 mm area with ~10μm lateral resolution, the presented system offers a super low cost, easy to use alternative to commercially available label-free systems.
Conference Presentation
© (2016) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Ugur Aygun, Ugur Aygun, Oguzhan Avci, Oguzhan Avci, Elif Seymour, Elif Seymour, Derin D. Sevenler, Derin D. Sevenler, Hakan Urey, Hakan Urey, M. Selim Ünlü, M. Selim Ünlü, Ayca Yalcin Ozkumur, Ayca Yalcin Ozkumur, } "Low cost flatbed scanner label-free biosensor", Proc. SPIE 9699, Optics and Biophotonics in Low-Resource Settings II, 969906 (7 March 2016); doi: 10.1117/12.2214113; https://doi.org/10.1117/12.2214113
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