18 March 2016 Spatially resolved diffuse reflectance spectroscopy of two-layer turbid media by densely packed multi-pixel photodiode reflectance probe
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Abstract
Spatially–resolved diffuse reflectance (SRDR) measurements provide photon path information, and enable layered tissue analysis. This paper presents experimental SRDR measurements on two-layer PDMS skin tissue-mimicking phantoms of varying top layer thicknesses, and bulk phantoms of varying optical properties using concentric multi-pixel photodiode array (CMPA) probes, and corresponding forward Monte Carlo simulations. The CMPA is the most densely packed semiconductor SRDR probe reported to date. Signal contrasts between the single layer phantom and bi-layer phantoms with varying top layer thicknesses are as high as 80%. The mean error between the Monte Carlo simulations and the experiment is less than 6.2 %.
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Ozlem Senlik, Ozlem Senlik, Gage Greening, Gage Greening, Timothy J. Muldoon, Timothy J. Muldoon, Nan M. Jokerst, Nan M. Jokerst, "Spatially resolved diffuse reflectance spectroscopy of two-layer turbid media by densely packed multi-pixel photodiode reflectance probe", Proc. SPIE 9700, Design and Quality for Biomedical Technologies IX, 97000O (18 March 2016); doi: 10.1117/12.2213124; https://doi.org/10.1117/12.2213124
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