7 March 2016 In vivo detection of cervical intraepithelial neoplasia by multimodal colposcopy
Author Affiliations +
Proceedings Volume 9701, Multimodal Biomedical Imaging XI; 97010E (2016); doi: 10.1117/12.2212194
Event: SPIE BiOS, 2016, San Francisco, California, United States
Abstract
Cervical cancer is the leading cause of cancer death for women in developing countries. Colposcopy plays an important role in early screening and detection of cervical intraepithelial neoplasia (CIN). In this paper, we developed a multimodal colposcopy system that combines multispectral reflectance, autofluorescence, and RGB imaging for in vivo detection of CIN, which is capable of dynamically recording multimodal data of the same region of interest (ROI). We studied the optical properties of cervical tissue to determine multi-wavelengths for different imaging modalities. Advanced algorithms based on the second derivative spectrum and the fluorescence intensity were developed to differentiate cervical tissue into two categories: squamous normal (SN) and high grade (HG) dysplasia. In the results, the kinetics of cervical reflectance and autofluorescence characteristics pre and post acetic acid application were observed and analyzed, and the image segmentation revealed good consistency with the gold standard of histopathology. Our pilot study demonstrated the clinical potential of this multimodal colposcopic system for in vivo detection of cervical cancer.
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Conference Presentation
Wenqi Ren, Yingjie Qu, Jiaojiao Pei, Linlin Xiao, Shiwu Zhang, Shufang Chang, Zachary J. Smith, Ronald X. Xu, "In vivo detection of cervical intraepithelial neoplasia by multimodal colposcopy", Proc. SPIE 9701, Multimodal Biomedical Imaging XI, 97010E (7 March 2016); doi: 10.1117/12.2212194; http://dx.doi.org/10.1117/12.2212194
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KEYWORDS
Tissues

Reflectivity

Image segmentation

Image enhancement

RGB color model

Multispectral imaging

Image processing

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