7 March 2016 Towards the mid-infrared optical biopsy
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Abstract
We are establishing a new paradigm in mid-infrared molecular sensing, mapping and imaging to open up the midinfrared spectral region for in vivo (i.e. in person) medical diagnostics and surgery. Thus, we are working towards the mid-infrared optical biopsy (‘opsy’ look at, bio the biology) in situ in the body for real-time diagnosis. This new paradigm will be enabled through focused development of devices and systems which are robust, functionally designed, safe, compact and cost effective and are based on active and passive mid-infrared optical fibers. In particular, this will enable early diagnosis of external cancers, mid-infrared detection of cancer-margins during external surgery for precise removal of diseased tissue, in one go during the surgery, and mid-infrared endoscopy for early diagnosis of internal cancers and their precision removal. The mid-infrared spectral region has previously lacked portable, bright sources. We set a record in demonstrating extreme broad-band supercontinuum generated light 1.4 to 13.3 microns in a specially engineered, high numerical aperture mid-infrared optical fiber. The active mid-infrared fiber broadband supercontinuum for the first time offers the possibility of a bright mid-infrared wideband source in a portable package as a first step for medical fiber-based systems operating in the mid-infrared. Moreover, mid-infrared molecular mapping and imaging is potentially a disruptive technology to give improved monitoring of the environment, energy efficiency, security, agriculture and in manufacturing and chemical processing. This work is in part supported by the European Commission: Framework Seven (FP7) Large-Scale Integrated Project MINERVA: MId-to-NEaR- infrared spectroscopy for improVed medical diAgnostics (317803; www.minerva-project.eu).
© (2016) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Angela B. Seddon, Angela B. Seddon, Trevor M. Benson, Trevor M. Benson, Slawomir Sujecki, Slawomir Sujecki, Nabil Abdel-Moneim, Nabil Abdel-Moneim, Zhuoqi Tang, Zhuoqi Tang, David Furniss, David Furniss, Lukasz Sojka, Lukasz Sojka, Nick Stone, Nick Stone, Nallala Jayakrupakar, Nallala Jayakrupakar, Gavin Rhys Lloyd, Gavin Rhys Lloyd, Ian Lindsay, Ian Lindsay, Jon Ward, Jon Ward, Mark Farries, Mark Farries, Peter M. Moselund, Peter M. Moselund, Bruce Napier, Bruce Napier, Samir Lamrini, Samir Lamrini, Uffe Møller, Uffe Møller, Irnis Kubat, Irnis Kubat, Christian R. Petersen, Christian R. Petersen, Ole Bang, Ole Bang, "Towards the mid-infrared optical biopsy", Proc. SPIE 9703, Optical Biopsy XIV: Toward Real-Time Spectroscopic Imaging and Diagnosis, 970302 (7 March 2016); doi: 10.1117/12.2211584; https://doi.org/10.1117/12.2211584
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