7 March 2016 Development and clinical translation of OTIS: a wide-field OCT imaging device for ex-vivo tissue characterization
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Abstract
We have developed an automated, wide-field optical coherence tomography (OCT)-based imaging device (OTISTM Perimeter Medical Imaging) for peri-operative, ex-vivo tissue imaging. This device features automated image acquisition, enabling rapid capture of high-resolution (15 μm) OCT images from samples up to 10 cm in diameter. We report on the iterative progression of device development from phantom and pre-clinical (tumor xenograft) models through to initial clinical results. We discuss the challenges associated with proving a novel imaging technology against the clinical “gold standard” of conventional post-operative pathology.
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Elizabeth A. Munro, Elizabeth A. Munro, David Rempel, David Rempel, Christine Danner, Christine Danner, Yaaseen Atchia, Yaaseen Atchia, Michael S. Valic, Michael S. Valic, Andrew Berkeley, Andrew Berkeley, Bahar Davoudi, Bahar Davoudi, Paul A. Magnin, Paul A. Magnin, Margarete Akens, Margarete Akens, Susan J. Done, Susan J. Done, Supriya Kulkarni, Supriya Kulkarni, Wey-Liang Leong, Wey-Liang Leong, Brian C. Wilson, Brian C. Wilson, } "Development and clinical translation of OTIS: a wide-field OCT imaging device for ex-vivo tissue characterization", Proc. SPIE 9703, Optical Biopsy XIV: Toward Real-Time Spectroscopic Imaging and Diagnosis, 97030L (7 March 2016); doi: 10.1117/12.2218467; https://doi.org/10.1117/12.2218467
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