Label-free pathological evaluation of grade 3 cancer using Stokes shift spectroscopy

Laura A. Sordillo; Peter P. Sordillo; R. R. Alfano

doi:10.1117/12.2214327

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11 March 2016 Label-free pathological evaluation of grade 3 cancer using Stokes shift spectroscopy

Laura A. Sordillo; Peter P. Sordillo; R. R. Alfano

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Proceedings Volume 9703, Optical Biopsy XIV: Toward Real-Time Spectroscopic Imaging and Diagnosis; 97030W (2016) https://doi.org/10.1117/12.2214327
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

In this study, Stokes shift spectroscopy (S3) is used for measuring the aggressiveness of malignant tumors. S3 is an optical tool which utilizes the difference between the emission wavelength (λem) and the absorption wavelength (λabs) (the Stokes shift) to give a fixed wavelength shift (Δλs).Our analysis of tumor samples using S3 shows grade 3 (high grade) cancers consistently have increased relative tryptophan content compared to grade 1 or 2 tumors. This technique may be a useful tool in the evaluation of a patient’s cancer.

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Laura A. Sordillo, Peter P. Sordillo, and R. R. Alfano "Label-free pathological evaluation of grade 3 cancer using Stokes shift spectroscopy", Proc. SPIE 9703, Optical Biopsy XIV: Toward Real-Time Spectroscopic Imaging and Diagnosis, 97030W (11 March 2016); https://doi.org/10.1117/12.2214327

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