7 March 2016 Penetration depth in tissue-mimicking phantoms from hyperspectral imaging in SWIR in transmission and reflection geometry
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Abstract
We explored the depth penetration in tissue-mimicking intralipid-based phantoms in SWIR (800-1650 nm) using a hyperspectral imaging system composed from a 2D CCD camera coupled to a microscope. Hyperspectral images in transmission and reflection geometries were collected with a spectral resolution of 5.27 nm and a total acquisition time of 3 minutes or less that minimized artifacts from sample drying. Michelson spatial contrast was used as a metric to evaluate light penetration. Results from both transmission and reflection geometries consistently revealed the highest spatial contrast in the wavelength range of 1300 to 1350 nm.
Conference Presentation
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Hairong Zhang, Hairong Zhang, Daniel Salo, Daniel Salo, David M. Kim, David M. Kim, Mikhail Y. Berezin, Mikhail Y. Berezin, "Penetration depth in tissue-mimicking phantoms from hyperspectral imaging in SWIR in transmission and reflection geometry", Proc. SPIE 9703, Optical Biopsy XIV: Toward Real-Time Spectroscopic Imaging and Diagnosis, 970311 (7 March 2016); doi: 10.1117/12.2213754; https://doi.org/10.1117/12.2213754
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