Steady state fluorescence spectroscopic characterization of normal and diabetic urine at selective excitation wavelength 280 nm

Anjana Kesavan; Rekha Pachaiappan; Prakasa Rao Aruna; Singaravelu Ganesan

doi:10.1117/12.2212625

7 March 2016 Steady state fluorescence spectroscopic characterization of normal and diabetic urine at selective excitation wavelength 280 nm

Anjana Kesavan, Rekha Pachaiappan, Prakasa Rao Aruna, Singaravelu Ganesan

Author Affiliations +

Proceedings Volume 9703, Optical Biopsy XIV: Toward Real-Time Spectroscopic Imaging and Diagnosis; 97031H (2016) https://doi.org/10.1117/12.2212625
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Urine is considered diagnostically important for tits native fluorophores and they vary in their distribution, concentration and physiochemical properties, depending upon the metabolic condition of the subject. In this study, we have made an attempt, to characterize the urine of normal subject and diabetic patients under medication by native fluorescence spectroscopy at 280 nm excitation. Further, the fluorescence data were analyzed employing the multivariate statistical method linear discriminant analysis (LDA) using leave one out cross validation method. The results were promising in discriminating diabetic urine from that of normal urine. This study in future may be extended to check the feasibility in ruling out the coexisting disorders such as cancer.

Conference Presentation

Citation Download Citation

Anjana Kesavan, Rekha Pachaiappan, Prakasa Rao Aruna, and Singaravelu Ganesan "Steady state fluorescence spectroscopic characterization of normal and diabetic urine at selective excitation wavelength 280 nm", Proc. SPIE 9703, Optical Biopsy XIV: Toward Real-Time Spectroscopic Imaging and Diagnosis, 97031H (7 March 2016); https://doi.org/10.1117/12.2212625

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