7 March 2016 Raman spectroscopy of bio fluids: an exploratory study for oral cancer detection
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Abstract
ion for various disease diagnosis including cancers. Oral cancer is one of the most common cancers in India and it accounts for one third of the global oral cancer burden. Raman spectroscopy of tissues has gained much attention in the diagnostic oncology, as it provides unique spectral signature corresponding to metabolic alterations under different pathological conditions and micro-environment. Based on these, several studies have been reported on the use of Raman spectroscopy in the discrimination of diseased conditions from their normal counterpart at cellular and tissue level but only limited studies were available on bio-fluids. Recently, optical characterization of bio-fluids has also geared up for biomarker identification in the disease diagnosis. In this context, an attempt was made to study the metabolic variations in the blood, urine and saliva of oral cancer patients and normal subjects using Raman spectroscopy. Principal Component based Linear Discriminant Analysis (PC-LDA) followed by Leave-One-Out Cross-Validation (LOOCV) was employed to find the statistical significance of the present technique in discriminating the malignant conditions from normal subjects.
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Elumalai Brindha, Elumalai Brindha, Ramu Rajasekaran, Ramu Rajasekaran, Prakasarao Aruna, Prakasarao Aruna, Dornadula Koteeswaran, Dornadula Koteeswaran, Singaravelu Ganesan, Singaravelu Ganesan, } "Raman spectroscopy of bio fluids: an exploratory study for oral cancer detection", Proc. SPIE 9703, Optical Biopsy XIV: Toward Real-Time Spectroscopic Imaging and Diagnosis, 97031T (7 March 2016); doi: 10.1117/12.2212684; https://doi.org/10.1117/12.2212684
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