7 March 2016 In vivo confocal Raman spectroscopy study of the vitamin A derivative perfusion through human skin
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Abstract
In vivo confocal Raman spectroscopy is a powerful non-invasive technique able to analyse the skin constituents. This technique was applied to transdermal perfusion studies of the vitamin A derivative in human skin. The composition of the stratum corneum (lipid bilayer) is decisive for the affinity and transport of the vitamin through skin. The vitamin A is significantly absorbed by human skin when applied with water in oil emulsion or hydro-alcoholic gel. The purpose of this study is to elucidate the behaviour of vitamin A derivative into human skin without the presence of enhancers. The results showed that the intensity band of the derivative (around 1600 cm-1), which represents the -C=O vibrational mode, was detected in different stratum corneum depths (up to 20 μm). This Raman peak of vitamin A derivative has non-coincident band with the Raman spectra of the skin epidermis, demonstrating that compound penetrated in forearm skin.
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Laurita dos Santos, Claudio A. Téllez Soto, Priscila P. Favero, Airton A. Martin, "In vivo confocal Raman spectroscopy study of the vitamin A derivative perfusion through human skin", Proc. SPIE 9704, Biomedical Vibrational Spectroscopy 2016: Advances in Research and Industry, 97040P (7 March 2016); doi: 10.1117/12.2214400; https://doi.org/10.1117/12.2214400
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