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18 March 2016 Tacky COC: a solvent bonding technique for fabrication of microfluidic systems
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The academic community knows cyclic olefin copolymer (COC) as a well suited material for microfluidic applications because COC has numerous interesting properties such as high transmittance, good chemical resistance and good biocompatibility. Here we present a fast and cost-effective method for bonding of two COC substrates: exposure to appropriate solvents gives a tacky COC surface which when brought in contact with untreated COC forms a strong and optical clear bond. The bonding process is carried out at room temperature and takes less than three minutes which makes it significantly faster than currently described methods: This method does not require special lab equipment such as hot plates or hydraulic presses. The mild conditions of the bond process also allow for such “tacky COC” lids to be used for sealing of microfluidic chips containing immobilized protein patterns which is of high interest for immunodiagnostic testing inside microfluidic chips.
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Nico Keller, Tobias M. Nargang, Dorothea Helmer, and Bastian E. Rapp "Tacky COC: a solvent bonding technique for fabrication of microfluidic systems", Proc. SPIE 9705, Microfluidics, BioMEMS, and Medical Microsystems XIV, 970507 (18 March 2016);

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