18 March 2016 Modular microfluidic cartridge-based universal diagnostic system for global health applications
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Abstract
Current microfluidics-enabled point-of-care diagnostic systems are typically designed specifically for one assay type, e.g. a molecular diagnostic assay for a single disease of a class of diseases. This approach often leads to high development cost and a significant training requirement for users of different instruments. We have developed an open platform diagnostic system which allows to run molecular, immunological and clinical assays on a single instrument platform with a standardized microfluidic cartridge architecture in an automated sample-in answer-out fashion. As examples, a molecular diagnostic assay for tuberculosis, an immunoassay for HIV p24 and a clinical chemistry assay for ALT liver function have been developed and results of their pre-clinical validation are presented.
Conference Presentation
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Holger Becker, Holger Becker, Richard Klemm, Richard Klemm, William Dietze, William Dietze, Wallace White, Wallace White, Nadine Hlawatsch, Nadine Hlawatsch, Susanne Freyberg, Susanne Freyberg, Christian Moche, Christian Moche, Peter Dailey, Peter Dailey, Claudia Gärtner, Claudia Gärtner, } "Modular microfluidic cartridge-based universal diagnostic system for global health applications", Proc. SPIE 9705, Microfluidics, BioMEMS, and Medical Microsystems XIV, 970514 (18 March 2016); doi: 10.1117/12.2217892; https://doi.org/10.1117/12.2217892
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