15 March 2016 Multi-acoustic lens design methodology for a low cost C-scan photoacoustic imaging camera
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We have designed and implemented a novel acoustic lens based focusing technology into a prototype photoacoustic imaging camera. All photoacoustically generated waves from laser exposed absorbers within a small volume get focused simultaneously by the lens onto an image plane. We use a multi-element ultrasound transducer array to capture the focused photoacoustic signals. Acoustic lens eliminates the need for expensive data acquisition hardware systems, is faster compared to electronic focusing and enables real-time image reconstruction. Using this photoacoustic imaging camera, we have imaged more than 150 several centimeter size ex-vivo human prostate, kidney and thyroid specimens with a millimeter resolution for cancer detection. In this paper, we share our lens design strategy and how we evaluate the resulting quality metrics (on and off axis point spread function, depth of field and modulation transfer function) through simulation. An advanced toolbox in MATLAB was adapted and used for simulating a two-dimensional gridded model that incorporates realistic photoacoustic signal generation and acoustic wave propagation through the lens with medium properties defined on each grid point. Two dimensional point spread functions have been generated and compared with experiments to demonstrate the utility of our design strategy. Finally we present results from work in progress on the use of two lens system aimed at further improving some of the quality metrics of our system.
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Bhargava Chinni, Bhargava Chinni, Zichao Han, Zichao Han, Nicholas Brown, Nicholas Brown, Pedro Vallejo, Pedro Vallejo, Tess Jacobs, Tess Jacobs, Wayne Knox, Wayne Knox, Vikram Dogra, Vikram Dogra, Navalgund Rao, Navalgund Rao, } "Multi-acoustic lens design methodology for a low cost C-scan photoacoustic imaging camera", Proc. SPIE 9708, Photons Plus Ultrasound: Imaging and Sensing 2016, 97081Q (15 March 2016); doi: 10.1117/12.2212933; https://doi.org/10.1117/12.2212933

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