High speed photoacoustic imaging with fast OPO laser at 1.7 μm (Conference Presentation)

Zhonglie Piao; Ma Teng; Jiawen Li; Yueqiao Qu; Mingyue Yu; K. Kirk Shung; Qifa Zhou; Chang-Seok Kim; Zhongping Chen

doi:10.1117/12.2214074

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28 April 2016 High speed photoacoustic imaging with fast OPO laser at 1.7 μm (Conference Presentation)

Zhonglie Piao; Ma Teng; Jiawen Li; Yueqiao Qu; Mingyue Yu; K. Kirk Shung; Qifa Zhou; Chang-Seok Kim; Zhongping Chen

Author Affiliations +

Zhonglie Piao
Beckman Laser Institute and Clinic, Univ. of California, Irvine (United States)
Ma Teng
The Univ. of Southern California (United States)
Jiawen Li
Beckman Laser Institute and Clinic, Univ. of California, Irvine (United States)
Yueqiao Qu
Beckman Laser Institute and Clinic, University of California, Irvine (United States)
Mingyue Yu , K. Kirk Shung , Qifa Zhou
The Univ. of Southern California (United States)
Chang-Seok Kim
Pusan National Univ. (Korea, Republic of)
Zhongping Chen
Beckman Laser Institute and Clinic, Univ. of California, Irvine (United States)

Proceedings Volume 9708, Photons Plus Ultrasound: Imaging and Sensing 2016; 97082T (2016) https://doi.org/10.1117/12.2214074
Event: SPIE BiOS, 2016, San Francisco, California, United States

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Abstract

Acute cardiovascular events are mostly due to a blood clot or thrombus induced by the sudden rupture of vulnerable atherosclerotic plaques within coronary artery walls. Based on the high optical absorption contrast of the lipid rich plaques within the vessel wall, intravascular photoacoustic (IVPA) imaging at 1.7 μm spectral band has shown promising capabilities for detecting of lipid composition, but the translation of the technology for in vivo application is limited by the slow imaging speed. In this work, we will present a high speed integrated IVPA/US imaging system with a 500 Hz optical parametric oscillator laser at 1725 nm (5 nm linewidth). A miniature catheter with 1.0 mm outer diameter was designed with a polished 200 μm multimode fiber and an ultrasound transducer with 45 MHz center frequency. Two optical illumination methods by gradient-index (GRIN) lens and ball lens are introduced and compared for higher spatial resolution. At 1725 nm, atherosclerotic rabbit abdominal aorta was imaged at two frame per second, which is more than one order of magnitude faster than previous reported IVPA imaging. Furthermore, by wide tuning range of the laser wavelength from 1680 nm to 1770 nm, spectroscopic photoacoustic analysis of lipid-mimicking phantom and an human atherosclerotic artery was performed ex vivo.

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Zhonglie Piao, Ma Teng, Jiawen Li, Yueqiao Qu, Mingyue Yu, K. Kirk Shung, Qifa Zhou, Chang-Seok Kim, and Zhongping Chen "High speed photoacoustic imaging with fast OPO laser at 1.7 μm (Conference Presentation)", Proc. SPIE 9708, Photons Plus Ultrasound: Imaging and Sensing 2016, 97082T (28 April 2016); doi: 10.1117/12.2214074; https://doi.org/10.1117/12.2214074

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KEYWORDS

Optical parametric oscillators

Photoacoustic imaging

Photoacoustic spectroscopy

Arteries

Gradient-index optics

Medical laser equipment

Ultrasonography

Absorption

Blood

In vivo imaging

Show All Keywords

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Zhonglie Piao, Ma Teng, Jiawen Li, Yueqiao Qu, Mingyue Yu, K. Kirk Shung, Qifa Zhou, Chang-Seok Kim, Zhongping Chen, "High speed photoacoustic imaging with fast OPO laser at 1.7 μm (Conference Presentation)," Proc. SPIE 9708, Photons Plus Ultrasound: Imaging and Sensing 2016, 97082T (28 April 2016);

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