15 March 2016 Photoacoustic imaging and surface-enhanced Raman spectroscopy using dual modal contrast agents
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Abstract
Recently, photoacoustic tomography (PAT) has emerged as a remarkable non-invasive imaging modality that provides a strong optical absorption contrast, high ultrasonic resolution, and great penetration depth. Thus, PAT has been widely used as an in vivo preclinical imaging tool. Surface-enhanced Raman spectroscopy (SERS) is another attractive sensing technology in biological research because it offers highly sensitive chemical analyses and multiplexed detection. By performing dual-modal imaging of SERS and PAT, high-resolution structural PAT imaging and high-sensitivity SERS sensing can be achieved. At the same time, it is equally important to develop a dual modal contrast agent for this purpose. To perform both PAT and SERS, we synthesized PEGylated silver bumpy nanoshells (AgBSs). The AgBSs generate strong PA signals owing to their strong optical absorption properties as well as sensitive SERS signals because of the surface plasmon resonance effect. Then, multiplexed Raman chemicals were synthesized to enhance the sensitivity of Raman. We have photoacoustically imaged the sentinel lymph nodes of small animals after intradermal injection of multiplexed agents. Furthermore, the chemical composition of each agent has been distinguished through SERS.
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Sungjo Park, Sungjo Park, Seunghyun Lee, Seunghyun Lee, Myeonggeun Cha, Myeonggeun Cha, Cheolhwan Jeong, Cheolhwan Jeong, Homan Kang, Homan Kang, So Yeon Park, So Yeon Park, Yoon-sik Lee, Yoon-sik Lee, Daehong Jeong, Daehong Jeong, Chulhong Kim, Chulhong Kim, } "Photoacoustic imaging and surface-enhanced Raman spectroscopy using dual modal contrast agents", Proc. SPIE 9708, Photons Plus Ultrasound: Imaging and Sensing 2016, 970839 (15 March 2016); doi: 10.1117/12.2211837; https://doi.org/10.1117/12.2211837
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