15 March 2016 Bessel beam Grueneisen photoacoustic microscopy with extended depth of field
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Abstract
The short focal depth of a Gaussian beam limits the volumetric imaging speed of optical resolution photoacoustic microscopy (OR-PAM). A Bessel beam, which is diffraction-free, provides a long focal depth, but its side-lobes may deteriorate image quality when the Bessel beam is directly employed to excite photoacoustic signals in ORPAM. Here, we present a nonlinear approach based on the Grueneisen relaxation effect to suppress the side-lobe artifacts in photoacoustic imaging. This method extends the focal depth of OR-PAM and speeds up volumetric imaging. We experimentally demonstrated a 1-mm focal depth with a 7-μm lateral resolution and volumetrically imaged a carbon fiber and red blood cell samples.
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Junhui Shi, Lidai Wang, Cedric Noordam, Lihong V. Wang, "Bessel beam Grueneisen photoacoustic microscopy with extended depth of field", Proc. SPIE 9708, Photons Plus Ultrasound: Imaging and Sensing 2016, 97083H (15 March 2016); doi: 10.1117/12.2211198; https://doi.org/10.1117/12.2211198
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