15 March 2016 Contrast-enhanced photoacoustic tomography of human joints
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Abstract
Photoacoustic tomography (PAT) provides a unique tool to diagnose inflammatory arthritis. However, the specificity and sensitivity of PAT based on endogenous contrasts is limited. The development of contrast enhanced PAT imaging modalities in combination with small molecule contrast agents could lead to improvements in diagnosis and treatment of joint disease. Accordingly, we adapted and tested a PAT clinical imaging system for imaging the human joints, in combination with a novel PAT contrast agent derived from an FDA-approved small molecule drug. Imaging results based on a photoacoustic and ultrasound (PA/US) dual-modality system revealed that this contrast-enhanced PAT imaging system may offer additional information beyond single-modality PA or US imaging system, for the imaging, diagnosis and assessment of inflammatory arthritis.
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Chao Tian, Chao Tian, Rahul K. Keswani, Rahul K. Keswani, Girish Gandikota, Girish Gandikota, Gus R. Rosania, Gus R. Rosania, Xueding Wang, Xueding Wang, "Contrast-enhanced photoacoustic tomography of human joints", Proc. SPIE 9708, Photons Plus Ultrasound: Imaging and Sensing 2016, 97084L (15 March 2016); doi: 10.1117/12.2213749; https://doi.org/10.1117/12.2213749
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