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15 March 2016 High-speed pre-clinical brain imaging using pulsed laser diode based photoacoustic tomography (PLD-PAT) system
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Abstract
Photoacoustic tomography (PAT) is a promising biomedical imaging modality for small animal imaging, breast cancer imaging, monitoring of vascularisation, tumor angiogenesis, blood oxygenation, total haemoglobin concentration etc. The existing PAT systems that uses Q-switched Nd:YAG and OPO nanosecond lasers have limitations in clinical applications because they are expensive, non-potable and not suitable for real-time imaging due to their low pulse repetition rate. Low-energy pulsed near-infrared diode laser which are low-cost, compact, and light-weight (<200 grams), can be used as an alternate. In this work, we present a photoacoustic tomography system with a pulsed laser diode (PLD) that can nanosecond pulses with pulse energy 1.3 mJ/pulse at ~803 nm wavelength and 7000 Hz repetition rate. The PLD is integrated inside a single-detector circular scanning geometric system. To verify the high speed imaging capabilities of the PLD-PAT system, we performed in vivo experimental results on small animal brain imaging using this system. The proposed system is portable, low-cost and can provide real-time imaging.
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Paul Kumar Upputuri and Manojit Pramanik "High-speed pre-clinical brain imaging using pulsed laser diode based photoacoustic tomography (PLD-PAT) system", Proc. SPIE 9708, Photons Plus Ultrasound: Imaging and Sensing 2016, 97084R (15 March 2016); https://doi.org/10.1117/12.2211891
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