22 March 2016 Towards ultrahigh resting-state functional connectivity in the mouse brain using photoacoustic microscopy
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Abstract
The increasing use of mouse models for human brain disease studies, coupled with the fact that existing high-resolution functional imaging modalities cannot be easily applied to mice, presents an emerging need for a new functional imaging modality. Utilizing both mechanical and optical scanning in the photoacoustic microscopy, we can image spontaneous cerebral hemodynamic fluctuations and their associated functional connections in the mouse brain. The images is going to be acquired noninvasively with a fast frame rate, a large field of view, and a high spatial resolution. We developed an optical resolution photoacoustic microscopy (OR-PAM) with diode laser. Laser light was raster scanned due to XY-stage movement. Images from ultra-high OR-PAM can then be used to study brain disorders such as stroke, Alzheimer’s, schizophrenia, multiple sclerosis, autism, and epilepsy.
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Ali Hariri, Ali Hariri, Nicholas Bely, Nicholas Bely, Chen Chen, Chen Chen, Mohammadreza Nasiriavanaki, Mohammadreza Nasiriavanaki, "Towards ultrahigh resting-state functional connectivity in the mouse brain using photoacoustic microscopy", Proc. SPIE 9708, Photons Plus Ultrasound: Imaging and Sensing 2016, 97085A (22 March 2016); doi: 10.1117/12.2224888; https://doi.org/10.1117/12.2224888
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