Photoacoustic image-guided drug delivery in the prostate

Shanshan Tang; Jian Chen; Pratik Samant; Liangzhong Xiang

doi:10.1117/12.2211061

9 March 2016 Photoacoustic image-guided drug delivery in the prostate

Shanshan Tang, Jian Chen, Pratik Samant, Liangzhong Xiang

Proceedings Volume 9709, Biophotonics and Immune Responses XI; 97090L (2016) https://doi.org/10.1117/12.2211061
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Image guided drug delivery is a novel strategy that combines the effect of therapy and visibility into one system. Here we apply photoacoustic (PA) imaging to visualize the drug delivery process, and perform a simulation study on monitoring the photosensitizer concentration in a prostate tumor during photodynamic therapy (PDT). A 3D optical model of the human prostate is developed, and the light absorption distribution in the prostate is estimated by the Monte Carlo simulation method. The filtered back-projection algorithm is used to reconstruct PA images. PA images of transurethral laser/transrectal ultrasound are compared to those of transrectal laser/ultrasound. Results show that the transurethral laser has a better penetration depth in the prostate compared with transrectal one. Urethral thermal safety is investigated via COMSOL Multiphysics, and the results show that the proposed pulsed transurethral laser will cause no thermal damage on the urethral surface. Regression analysis for PA signal amplitude and drug concentration demonstrates that the PA technique has the potential to monitor drug distributions in PDT, as well as in other laser-based prostate therapy modalities.

Conference Presentation

Citation Download Citation

Shanshan Tang, Jian Chen, Pratik Samant, and Liangzhong Xiang "Photoacoustic image-guided drug delivery in the prostate", Proc. SPIE 9709, Biophotonics and Immune Responses XI, 97090L (9 March 2016); https://doi.org/10.1117/12.2211061

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