9 March 2016 Temperature distribution in target tumor tissue and photothermal tissue destruction during laser immunotherapy
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Proceedings Volume 9709, Biophotonics and Immune Responses XI; 97090N (2016) https://doi.org/10.1117/12.2209692
Event: SPIE BiOS, 2016, San Francisco, California, United States
Abstract
Laser Immunotherapy is a novel cancer treatment modality that has seen much success in treating many different types of cancer, both in animal studies and in clinical trials. The treatment consists of the synergistic interaction between photothermal laser irradiation and the local injection of an immunoadjuvant. As a result of the therapy, the host immune system launches a systemic antitumor response. The photothermal effect induced by the laser irradiation has multiple effects at different temperature elevations which are all required for optimal response. Therefore, determining the temperature distribution in the target tumor during the laser irradiation in laser immunotherapy is crucial to facilitate the treatment of cancers. To investigate the temperature distribution in the target tumor, female Wistar Furth rats were injected with metastatic mammary tumor cells and, upon sufficient tumor growth, underwent laser irradiation and were monitored using thermocouples connected to locally-inserted needle probes and infrared thermography. From the study, we determined that the maximum central tumor temperature was higher for tumors of less volume. Additionally, we determined that the temperature near the edge of the tumor as measured with a thermocouple had a strong correlation with the maximum temperature value in the infrared camera measurement.
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Austin Doughty, Aamr Hasanjee, Alex Pettitt, Kegan Silk, Hong Liu, Wei R. Chen, Feifan Zhou, "Temperature distribution in target tumor tissue and photothermal tissue destruction during laser immunotherapy", Proc. SPIE 9709, Biophotonics and Immune Responses XI, 97090N (9 March 2016); doi: 10.1117/12.2209692; https://doi.org/10.1117/12.2209692
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