Four-wave mixing based light sources for real-world biomedical applications of coherent Raman microscopy

Thomas Gottschall; Tobias Meyer; Cesar Jauregui; Michael Schmitt; Jürgen Popp; Jens Limpert; Andreas Tünnermann

doi:10.1117/12.2212213

14 March 2016 Four-wave mixing based light sources for real-world biomedical applications of coherent Raman microscopy

Thomas Gottschall, Tobias Meyer, Cesar Jauregui, Michael Schmitt, Jürgen Popp, Jens Limpert, Andreas Tünnermann

Proceedings Volume 9712, Multiphoton Microscopy in the Biomedical Sciences XVI; 971202 (2016) https://doi.org/10.1117/12.2212213
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Stimulated Raman Scattering requires an extremely quiet, widely wavelength tunable laser, which, up to now, is unheard of in fiber lasers. We present a compact and maintenance-free optical parametric oscillator based on degenerate four-wave mixing in a photonic crystal fiber. By employing an all-fiber frequency and repetition rate tunable laser as a seed source, we are able to generate tunable light between 1015 and 1065 nm. After amplification and subsequent conversion in the fiber OPO, signal and idler radiation between 785 and 960 nm and 1177 and 1500 nm may be generated with a repetition rate of 9 MHz. Therefore, we are able to address Raman shifts between 910 and 3030 cm^-1. An additional output provides the Stokes radiation at 18 MHz required for the SRS process, which is passively synchronized to the tunable radiation. We measure the relative intensity noise of the Stokes beam at 9 MHz to be -150 dBc enabling high speed SRS imaging with a good signal-to-noise ratio. The combination of FWM based conversion, coupled with all-fiber Yb-based fiber lasers allows for the first turn-key, widely tunable and extremely compact laser systems developed for applications of CRS microscopy in clinics. This source could very well be the missing key instrument that CRS imaging requires for its real world transition.

Citation Download Citation

Thomas Gottschall, Tobias Meyer, Cesar Jauregui, Michael Schmitt, Jürgen Popp, Jens Limpert, and Andreas Tünnermann "Four-wave mixing based light sources for real-world biomedical applications of coherent Raman microscopy", Proc. SPIE 9712, Multiphoton Microscopy in the Biomedical Sciences XVI, 971202 (14 March 2016); https://doi.org/10.1117/12.2212213

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available