A wearable optical device for continuous monitoring during neoadjuvant chemotherapy infusions

Fei Teng; Timothy Cormier; Alexis Sauer-Budge; Darren M. Roblyer

doi:10.1117/12.2208438

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4 March 2016 A wearable optical device for continuous monitoring during neoadjuvant chemotherapy infusions

Fei Teng, Timothy Cormier, Alexis Sauer-Budge, Darren M. Roblyer

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Proceedings Volume 9715, Optical Diagnostics and Sensing XVI: Toward Point-of-Care Diagnostics; 97150P (2016) https://doi.org/10.1117/12.2208438
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

We present a new continuous-wave (CW) wearable diffuse optical device aimed at investigating the hemodynamic response of locally advanced breast cancer patients during a patient’s first neoadjuvant chemotherapy infusion. The system consists of a flexible substrate that supports an array of surface-mount LED and photodiode pairs (i.e. optodes). Probe performance was evaluated using solid tissue-simulating phantoms. Measurements revealed high SNR (65dB), low source-detector crosstalk (-59 dB), high measurement precision (0.17%), and good thermal stability (0.2% V_rms/°C). A cuff occlusion experiment was performed on the forearm of a healthy volunteer to demonstrate the ability to track rapid hemodynamic changes.

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Fei Teng, Timothy Cormier, Alexis Sauer-Budge, and Darren M. Roblyer "A wearable optical device for continuous monitoring during neoadjuvant chemotherapy infusions", Proc. SPIE 9715, Optical Diagnostics and Sensing XVI: Toward Point-of-Care Diagnostics, 97150P (4 March 2016); https://doi.org/10.1117/12.2208438

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