Characterization of a multi-module tunable EC-QCL system for mid-infrared biofluid spectroscopy for hospital use and personalized diabetes technology

M. Grafen; K. Nalpantidis; A. Ostendorf; D. Ihrig; H. M. Heise

doi:10.1117/12.2213635

4 March 2016 Characterization of a multi-module tunable EC-QCL system for mid-infrared biofluid spectroscopy for hospital use and personalized diabetes technology

M. Grafen, K. Nalpantidis, A. Ostendorf, D. Ihrig, H. M. Heise

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Proceedings Volume 9715, Optical Diagnostics and Sensing XVI: Toward Point-of-Care Diagnostics; 97150T (2016) https://doi.org/10.1117/12.2213635
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Blood glucose monitoring systems are important point-of-care devices for the hospital and personalised diabetes technology. FTIR-spectrometers have been successfully employed for the development of continuous bed-side monitoring systems in combination with micro-dialysis. For implementation in miniaturised portable systems, external-cavity quantum cascade lasers (EC-QCL) are suited. An ultra-broadly tunable pulsed EC-QCL system, covering a spectral range from 1920 to 780 cm^-1, has been characterised with regard to the spectral emission profiles and wavenumber scale accuracy. The measurement of glucose in aqueous solution is presented and problems with signal linearity using Peltier-cooled MCT-detectors are discussed. The use of larger optical sample pathlengths for attenuating the laser power in transmission measurements has recently been suggested and implemented, but implications for broad mid-infrared measurements have now been investigated. The utilization of discrete wavenumber variables as an alternative for sweep-tune measurements has also been studied and sparse multivariate calibration models intended for clinical chemistry applications are described for glucose and lactate.

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M. Grafen, K. Nalpantidis, A. Ostendorf, D. Ihrig, and H. M. Heise "Characterization of a multi-module tunable EC-QCL system for mid-infrared biofluid spectroscopy for hospital use and personalized diabetes technology", Proc. SPIE 9715, Optical Diagnostics and Sensing XVI: Toward Point-of-Care Diagnostics, 97150T (4 March 2016); https://doi.org/10.1117/12.2213635

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