4 March 2016 A closed-loop dual-modulation multi-spectral polarimeter for glucose monitoring
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Abstract
Optical polarimetry is a promising noninvasive means of assessing glucose concentration in the aqueous humor of the eye. One the major limiting factors is time-varying cornea birefringence due to motion artifact, which prevents the realization of this device. In this study, we simultaneously utilize laser intensity modulation and Faraday polarization rotation modulation for a real-time closed-loop multi-spectral polarimeter for glucose monitoring in vitro. In this report, a real-time closed-loop dual-modulation dual-spectral polarimeter was presented and in vitro glucose measurements were performed demonstrating the accuracy and repeatability of this polarimeter.
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Zhen fang Yu, Zhen fang Yu, Casey W. Pirnstill, Casey W. Pirnstill, Gerard L. Coté, Gerard L. Coté, } "A closed-loop dual-modulation multi-spectral polarimeter for glucose monitoring", Proc. SPIE 9715, Optical Diagnostics and Sensing XVI: Toward Point-of-Care Diagnostics, 97150U (4 March 2016); doi: 10.1117/12.2211114; https://doi.org/10.1117/12.2211114
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