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22 April 2016 Engineering molecularly-active nanoplasmonic surfaces for DNA detection via colorimetry and Raman scattering
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Abstract
We report a novel nanophotonic biosensor surface capable of both colorimetric detection and Raman-scattered detection of DNA infection markers at extreme sensitivities. Combining direct-write lithography, dip-pen nanolithography based DNA patterning, and molecular self-assembly, we create molecularly-active plasmonic nanostructures onto which metallic nanoparticles are located via DNA-hybridization. Arraying these structures enables optical surfaces that change state when contacted by specific DNA sequences; shifting the surface color while simultaneously generating strong Raman-scattering signals. Patterning the DNA markers onto the plasmonic surface as micro-scale symbols results in easily identifiable color shifts, making this technique applicable to multiplexed lab-on-a-chip and point-of-care diagnostic applications.
Conference Presentation
© (2016) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Esmaeil Heydari, Samuel Mabbott, David Thompson, Duncan Graham, Jonathan M. Cooper, and Alasdair W. Clark "Engineering molecularly-active nanoplasmonic surfaces for DNA detection via colorimetry and Raman scattering", Proc. SPIE 9721, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIII, 972105 (22 April 2016); https://doi.org/10.1117/12.2209108
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