22 April 2016 Optoelectronic investigation of nanodiamond interactions with human blood
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Abstract
We present optoelectronic investigation of in vitro interactions of whole human blood with different nanodiamond biomarkers. Plasmo-chemical modifications of detonation nanodiamond particles gives the possibility for controlling their surface for biological applications. Optical investigations reveal the biological activity of nanodiamonds in blood dependent on its surface termination. We compare different types of nanodiamonds: commercial non-modified detonation nanodiamonds, and nanodiamonds modified by MW PACVD method with H2-termination, and chemically modified nanodiamond with O2-termination. The absorption spectra, and optical microscope investigations were conducted. The results indicate haemocompatibility of non-modified detonation nanodiamond as well as modified nanodiamonds, which enables their application for drug delivery, as well as sensing applications.
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M. Ficek, M. S. Wróbel, M. Wasowicz, and M. Jedrzejewska-Szczerska "Optoelectronic investigation of nanodiamond interactions with human blood", Proc. SPIE 9721, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIII, 97210H (22 April 2016); doi: 10.1117/12.2208443; https://doi.org/10.1117/12.2208443
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