22 April 2016 High specificity ZnO quantum dots for diagnosis and treatment in bacterial infection
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Abstract
Early diagnosis and effective treatment of bacterial infection has become increasingly important. Herein, we developed a fluorescent nano-probe MPA@ZnO-PEP by conjugating SiO2-stabilized ZnO quantum dot (ZnO@SiO2) with bacteria-targeting peptide PEP, which was encapsulated with MPA, a near infrared (NIR) dye. The nanoprobe MPA@ZnO-PEP showed excellent fluorescence property and could specifically distinguish bacterial infection from sterile inflammation both in vitro and in vivo. The favorable biocompatability of MPA@ZnO-PEP was verified by MTT assay. This probe was further modified with antibiotic methicillin to form the theranostic nanoparticle MPA/Met@ZnO-PEP with amplified antibacterial activity. These results promised the great potential of MPA@ZnO-PEP for efficient non-invasive early diagnosis of bacterial infections and effective bacterial-targeting therapy.
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Min Zhang, Min Zhang, Zhiyu Qian, Zhiyu Qian, Yueqing Gu, Yueqing Gu, "High specificity ZnO quantum dots for diagnosis and treatment in bacterial infection", Proc. SPIE 9723, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VIII, 972310 (22 April 2016); doi: 10.1117/12.2220034; https://doi.org/10.1117/12.2220034
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