22 April 2016 SERS sensing of sub-nanoliter analyte on diatom biosilica using inkjet printing
Author Affiliations +
Proceedings Volume 9724, Plasmonics in Biology and Medicine XIII; 972406 (2016) https://doi.org/10.1117/12.2214005
Event: SPIE BiOS, 2016, San Francisco, California, United States
Abstract
Diatoms are unicellular algae which have photonic-crystal-like biosilica frustules consisting of many pores. Each diatom frustule has a dimension around 10~20μm and can be used as a miniaturized biosensor. In this article, we demonstrate surface-enhanced Raman scattering (SERS) sensing of sub-nanoliter analyte on diatom biosilica with self-assembled silver nanoparticles (Ag NPs). An inkjet printer is used to dispense multiple ~100 pico-liter volume analyte droplets with pinpoint accuracy and precision onto each individual diatom frustule. Experimental results show up to 3x higher SERS signals of R6G on diatom compared with those from conventional colloidal SERS substrates. Furthermore, down to 10-14M R6G detection ability was also demonstrated through the inkjet printing strategy.
© (2016) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Yuting Xi, Yuting Xi, Xianming Kong, Xianming Kong, Kenny Squire, Kenny Squire, Paul LeDuff, Paul LeDuff, Gregory L. Rorrer, Gregory L. Rorrer, Alan X. Wang, Alan X. Wang, "SERS sensing of sub-nanoliter analyte on diatom biosilica using inkjet printing", Proc. SPIE 9724, Plasmonics in Biology and Medicine XIII, 972406 (22 April 2016); doi: 10.1117/12.2214005; https://doi.org/10.1117/12.2214005
PROCEEDINGS
6 PAGES


SHARE
Back to Top