9 March 2016 Phase-sensitive plasmonics biosensors: from bulk to nanoscale architechtures and novel functionalities
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Abstract
We overview our on-going activities on the improvement of physical sensitivity of plasmonic biosensors. Our approach is based on the employment of phase properties of light reflected from plasmonic transducer instead of amplitude ones in order to improve its detection limit in studies of bio-molecular interactions between a target analyte and its corresponding receptor. Originally, phase-sensitive bio-sensing concept was demonstrated in conventional Surface Plasmon Resonance (SPR) geometry using a thin Au film in Kretschmann-Raether arrangement, but the resulting sensitivity had some limitations because of a rough relief of the gold film surface. We then demonstrate the possibility for the extension of this concept to novel nanoscale architectures of designed plasmonic meta-materials in order to further improve the sensitivity of plasmonic bio-sensing technology. The latter approach also profits from much enhanced electric field in coupled nanostructures exposed to illumination, therefore enabling spectroscopy analysis (Raman, Fluorescence, IR etc) methods to increase sensitivity level (potentially down to single molecule).
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A. Danilov, V. G. Kravets, G. Tselikov, A. V. Grigorenko, A. V. Kabashin, "Phase-sensitive plasmonics biosensors: from bulk to nanoscale architechtures and novel functionalities", Proc. SPIE 9737, Synthesis and Photonics of Nanoscale Materials XIII, 97370D (9 March 2016); doi: 10.1117/12.2214883; https://doi.org/10.1117/12.2214883
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