23 March 2016 Brillouin microspectroscopy of nanostructured biomaterials: photonics assisted tailoring mechanical properties
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Abstract
Developing new biomaterials is essential for the next-generation of materials for bioenergy, bioelectronics, basic biology, medical diagnostics, cancer research, and regenerative medicine. Specifically, recent progress in nanotechnology has stimulated the development of multifunctional biomaterials for tissue engineering applications. The physical properties of nanocomposite biomaterials, including elasticity and viscosity, play key roles in controlling cell fate, which underlines therapeutic success. Conventional mechanical tests, including uniaxial compression and tension, dynamic mechanical analysis and shear rheology, require mechanical forces to be directly exerted onto the sample and therefore may not be suitable for in situ measurements or continuous monitoring of mechanical stiffness. In this study, we employ spontaneous Brillouin spectroscopy as a viscoelasticity-specific probing technique. We utilized a Brillouin spectrometer to characterize biomaterial’s microscopic elasticity and correlated those with conventional mechanical tests (e.g., rheology).
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Zhaokai Meng, Zhaokai Meng, Manish K. Jaiswal, Manish K. Jaiswal, Chandani Chitrakar, Chandani Chitrakar, Teena Thakur, Teena Thakur, Akhilesh K. Gaharwar, Akhilesh K. Gaharwar, Vladislav V. Yakovlev, Vladislav V. Yakovlev, } "Brillouin microspectroscopy of nanostructured biomaterials: photonics assisted tailoring mechanical properties", Proc. SPIE 9737, Synthesis and Photonics of Nanoscale Materials XIII, 97370G (23 March 2016); doi: 10.1117/12.2222816; https://doi.org/10.1117/12.2222816
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