With a use of electro-optic modulator based comb generator, ultra-wideband optical comb is stably and flexibly synthesized from a continuous-wave light. Larger modulation depth at a higher repetition rate would proportionally enhance bandwidth of the generated comb. Practically, however, achievable modulation depth is limited by available output power of microwave amplifiers. In addition, the repetition rate, i.e. comb spacing, is determined by system-side requirements. For example, frequency spacing of the generated comb should fit to the wavelength grid of optical fiber networks. Narrower frequency spacing is requested for photonic measurements assisted by advanced electrical signal processing based on low-speed electronics. In this paper, through numerical analysis, we propose and discuss configurations of serially cascaded Mach-Zehnder modulator-based flat comb generators, aiming for optical comb generation satisfying both higher bandwidth and narrower frequency spacing.