800-MeV magnetic-focused flash proton radiography for high-contrast imaging of low-density biologically-relevant targets using an inverse-scatter collimator

Matthew S. Freeman; Jason Allison; Camilo Espinoza; John Jerome Goett III; Gary Hogan; Brian Hollander; Kris Kwiatkowski; Julian Lopez; Fesseha Mariam; Michael Martinez; Jason Medina; Patrick Medina; Frank E. Merrill; Deborah Morley; Chris Morris; Matthew Murray; Paul Nedrow; Alexander Saunders; Tamsen Schurman; Thomas Sisneros; Amy Tainter; Frans Trouw; Dale Tupa; Josh Tybo; Carl Wilde

doi:10.1117/12.2216862

25 March 2016 800-MeV magnetic-focused flash proton radiography for high-contrast imaging of low-density biologically-relevant targets using an inverse-scatter collimator

Matthew S. Freeman, Jason Allison, Camilo Espinoza, John Jerome Goett III, Gary Hogan, Brian Hollander, Kris Kwiatkowski, Julian Lopez, Fesseha Mariam, Michael Martinez, Jason Medina, Patrick Medina, Frank E. Merrill, Deborah Morley, Chris Morris, Matthew Murray, Paul Nedrow, Alexander Saunders, Tamsen Schurman, Thomas Sisneros, Amy Tainter, Frans Trouw, Dale Tupa, Josh Tybo, Carl Wilde

Author Affiliations +

Proceedings Volume 9783, Medical Imaging 2016: Physics of Medical Imaging; 97831X (2016) https://doi.org/10.1117/12.2216862
Event: SPIE Medical Imaging, 2016, San Diego, California, United States

Abstract

Proton radiography shows great promise as a tool to guide proton beam therapy (PBT) in real time. Here, we demonstrate two ways in which the technology may progress towards that goal. Firstly, with a proton beam that is 800 MeV in energy, target tissue receives a dose of radiation with very tight lateral constraint. This could present a benefit over the traditional treatment energies of ~200 MeV, where up to 1 cm of lateral tissue receives scattered radiation at the target. At 800 MeV, the beam travels completely through the object with minimal deflection, thus constraining lateral dose to a smaller area. The second novelty of this system is the utilization of magnetic quadrupole refocusing lenses that mitigate the blur caused by multiple Coulomb scattering within an object, enabling high resolution imaging of thick objects, such as the human body. This system is demonstrated on ex vivo salamander and zebrafish specimens, as well as on a realistic hand phantom. The resulting images provide contrast sufficient to visualize thin tissue, as well as fine detail within the target volumes, and the ability to measure small changes in density. Such a system, combined with PBT, would enable the delivery of a highly specific dose of radiation that is monitored and guided in real time.

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Matthew S. Freeman, Jason Allison, Camilo Espinoza, John Jerome Goett III, Gary Hogan, Brian Hollander, Kris Kwiatkowski, Julian Lopez, Fesseha Mariam, Michael Martinez, Jason Medina, Patrick Medina, Frank E. Merrill, Deborah Morley, Chris Morris, Matthew Murray, Paul Nedrow, Alexander Saunders, Tamsen Schurman, Thomas Sisneros, Amy Tainter, Frans Trouw, Dale Tupa, Josh Tybo, and Carl Wilde "800-MeV magnetic-focused flash proton radiography for high-contrast imaging of low-density biologically-relevant targets using an inverse-scatter collimator", Proc. SPIE 9783, Medical Imaging 2016: Physics of Medical Imaging, 97831X (25 March 2016); https://doi.org/10.1117/12.2216862

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