25 March 2016 800-MeV magnetic-focused flash proton radiography for high-contrast imaging of low-density biologically-relevant targets using an inverse-scatter collimator
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Abstract
Proton radiography shows great promise as a tool to guide proton beam therapy (PBT) in real time. Here, we demonstrate two ways in which the technology may progress towards that goal. Firstly, with a proton beam that is 800 MeV in energy, target tissue receives a dose of radiation with very tight lateral constraint. This could present a benefit over the traditional treatment energies of ~200 MeV, where up to 1 cm of lateral tissue receives scattered radiation at the target. At 800 MeV, the beam travels completely through the object with minimal deflection, thus constraining lateral dose to a smaller area. The second novelty of this system is the utilization of magnetic quadrupole refocusing lenses that mitigate the blur caused by multiple Coulomb scattering within an object, enabling high resolution imaging of thick objects, such as the human body. This system is demonstrated on ex vivo salamander and zebrafish specimens, as well as on a realistic hand phantom. The resulting images provide contrast sufficient to visualize thin tissue, as well as fine detail within the target volumes, and the ability to measure small changes in density. Such a system, combined with PBT, would enable the delivery of a highly specific dose of radiation that is monitored and guided in real time.
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Matthew S. Freeman, Matthew S. Freeman, Jason Allison, Jason Allison, Camilo Espinoza, Camilo Espinoza, John Jerome Goett, John Jerome Goett, Gary Hogan, Gary Hogan, Brian Hollander, Brian Hollander, Kris Kwiatkowski, Kris Kwiatkowski, Julian Lopez, Julian Lopez, Fesseha Mariam, Fesseha Mariam, Michael Martinez, Michael Martinez, Jason Medina, Jason Medina, Patrick Medina, Patrick Medina, Frank E. Merrill, Frank E. Merrill, Deborah Morley, Deborah Morley, Chris Morris, Chris Morris, Matthew Murray, Matthew Murray, Paul Nedrow, Paul Nedrow, Alexander Saunders, Alexander Saunders, Tamsen Schurman, Tamsen Schurman, Thomas Sisneros, Thomas Sisneros, Amy Tainter, Amy Tainter, Frans Trouw, Frans Trouw, Dale Tupa, Dale Tupa, Josh Tybo, Josh Tybo, Carl Wilde, Carl Wilde, "800-MeV magnetic-focused flash proton radiography for high-contrast imaging of low-density biologically-relevant targets using an inverse-scatter collimator", Proc. SPIE 9783, Medical Imaging 2016: Physics of Medical Imaging, 97831X (25 March 2016); doi: 10.1117/12.2216862; https://doi.org/10.1117/12.2216862
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