29 March 2016 Optimal exposure techniques for iodinated contrast enhanced breast CT
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Abstract
Screening for breast cancer using mammography has been very successful in the effort to reduce breast cancer mortality, and its use has largely resulted in the 30% reduction in breast cancer mortality observed since 1990 [1]. However, diagnostic mammography remains an area of breast imaging that is in great need for improvement. One imaging modality proposed for improving the accuracy of diagnostic workup is iodinated contrast-enhanced breast CT [2]. In this study, a mathematical framework is used to evaluate optimal exposure techniques for contrast-enhanced breast CT. The ideal observer signal-to-noise ratio (i.e., d’) figure-of-merit is used to provide a task performance based assessment of optimal acquisition parameters under the assumptions of a linear, shift-invariant imaging system. A parallel-cascade model was used to estimate signal and noise propagation through the detector, and a realistic lesion model with iodine uptake was embedded into a structured breast background. Ideal observer performance was investigated across kVp settings, filter materials, and filter thickness. Results indicated many kVp spectra/filter combinations can improve performance over currently used x-ray spectra.
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Stephen J. Glick, Stephen J. Glick, Andrey Makeev, Andrey Makeev, "Optimal exposure techniques for iodinated contrast enhanced breast CT", Proc. SPIE 9783, Medical Imaging 2016: Physics of Medical Imaging, 97832N (29 March 2016); doi: 10.1117/12.2216806; https://doi.org/10.1117/12.2216806
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