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1 April 2016Direct reconstruction of enhanced signal in computed tomography perfusion
Bin Li,1,2 Qingwen Lyu,1,2 Jianhua Ma,1 Jing Wang3
1Southern Medical Univ. (China) 2Univ. of Texas Southwestern Medical Ctr. (United States) 3The Univ. of Texas Southwestern Medical Ctr. at Dallas (United States)
High imaging dose has been a concern in computed tomography perfusion (CTP) as repeated scans are performed at the
same location of a patient. On the other hand, signal changes only occur at limited regions in CT acquired at different
time points. In this work, we propose a new reconstruction strategy by effectively utilizing the initial phase high-quality
CT to reconstruct the later phase CT acquired with a low-dose protocol. In the proposed strategy, initial high-quality CT
is considered as a base image and enhanced signal (ES) is reconstructed directly by minimizing the penalized weighted
least-square (PWLS) criterion. The proposed PWLS-ES strategy converts the conventional CT reconstruction into a
sparse signal reconstruction problem. Digital and anthropomorphic phantom studies were performed to evaluate the
performance of the proposed PWLS-ES strategy. Both phantom studies show that the proposed PWLS-ES method
outperforms the standard iterative CT reconstruction algorithm based on the same PWLS criterion according to various
quantitative metrics including root mean squared error (RMSE) and the universal quality index (UQI).
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Bin Li, Qingwen Lyu, Jianhua Ma, Jing Wang, "Direct reconstruction of enhanced signal in computed tomography perfusion," Proc. SPIE 9783, Medical Imaging 2016: Physics of Medical Imaging, 97834L (1 April 2016); https://doi.org/10.1117/12.2216998